ABSTRACT
Background: Infections, drugs, surgical procedures, blood transfusions, solid and hematological cancers, and autoimmune disorders are associated with the risk of developing acquired FV inhibitors. Case report presentation: A 66-year-old Caucasian woman presented to the Emergency Department because of recurrent episodes of bowel bleeding from 2 week, and bleeding from the sites of venous sampling. Coagulation tests showed that the platelet count was normal: prolonged prothrombin time (PT): 45.5 seconds, international normalized ratio: 4.03, and activated partial thromboplastin time (aPTT): 165 seconds, aPTT ratio: 5.4. Coagulation factor II (FII), factor X (FX), factor VIII (FVIII), and fibrinogen were normal. The FV activity was 0.2% (range of normality 60-120%). The PT, aPTT, and one-stage coagulation factors assays were performed using an ACL TOP 550 coagulometer, and factor V was determined using a onestage PT-based assay, and factor V-deficient substrate plasma. Anticardiolipin antibodies were negative. Mixing test of patient's plasma with normal pooled plasma revealed the existence of an FV inhibitor, with an activity level of 4.0 Bethesda unit/mL. Three weeks before, the patient had been treated for coronavirus disease 2019 (COVID- 19) at home, with steroids (dexamethasone 6 mg daily for 5 days), enoxaparin 4,000 IU daily, and oxygen. Conclusions: The Authors presented a case report with acquired factor V inhibitor after SARS-CoV2 disease.
ABSTRACT
Background and Aim: The authors present the HISECOR study, an acronym deriving from High resolution computerized tomography SEverity score and CO-Rads. A retrospective analysis was performed on 30 patients enrolled with CoViD-19 pneumonia. The diagnosis was confirmed by the radiological picture (CT-CXR), by the positivity of the molecular swab for SARS-CoV2. A comparative analysis was performed with Student's parametric t test to check if there is a significant relationship between the values of the HRCT Severity Score and those of the CO-RADS at T0. The HISECOR study has the following objectives:1) check relationships between the HRCT Severity Score values and those of the CO-RADS at T0;2) verify the statistical significance found by applying Student's parametric test t. Materials and Methods: Student's t test calculates the relative value (VR) of t index to be associated with the difference found according to the following formula: t=(M1-M2)/√DS12/N1+ DS22/N2. Results: Student's t test applied to 30 patients shows a highly significant correlation (p <0.001) of the two variables examined (HRCT Severity Score and CO-RADS Score at T0) and not attributable to case. The value of t is 6.10 and the CV of t for p=0.001 is 3.65 with GL= 29. Conclusions: The HISECOR study demonstrated a statistically significant correlation between the HRCT Severity Score values and those of the CO-RADS Score obtained at T0.
ABSTRACT
Background and Aim: The Authors present the CHAVES study, acronym deriving from CHArlson comorbidy index - hrct seVErity Score, enrolling 30 patients with SARS-CoV-2 pneumonia. The diagnosis was confirmed by the radiological picture (CT-CXR), by the positivity of the molecular swab for SARS-CoV-2. All patients underwent HRCT at the time of admission and in all patients the HRCT Severity Score and the Charlson Comorbidy Index were calculated at T0. The CHAVES study has the following objectives: 1)check existing relationships between the HRCT Severity Score values and those of the Charlson Comorbidy Index at T0;2)verify the statistical significance found by applying Student's parametric test t as a comparative analysis test. Materials and Methods: Student's t test calculates the relative value (RV) of t index to be associated with the difference found according to the following formula: t=(M1-M2)/√DS12/N1 +DS22/N2. Results: Student's t test applied to 30 patients shows a highly significant correlation (p <0.001) of the two variables examined (HRCT Severity Score and Charlson Comorbidy Index values at T0). The value of t obtained is 4.71 and the CV (critical value) of t for p=0.001 is 3.65 with GL=29. Conclusions: The CHAVES study demonstrated a statistically significant correlation between the values of the HRCT Severity Score and those of the Charlson Comorbidy Index obtained at T0.
ABSTRACT
Background and Aim: The authors present the CODIPAF study, an acrostic deriving from sCOre raDIographic in pneumoCoViD-19 and oxygen PArtial pressure/inspiratory Fraction. A retrospective analysis was performed on 30 patients with CoViD-19 pneumonia. The diagnosis was confirmed by the radiological picture (CTCXR), by the positivity of the molecular swab for SARS-CoV-2.All patients underwent CRX on day 0 (T0) and on day 30 (T30),and in all patients it was calculated the P/F always at T0 and at T30.The CODIPAF study has the following objectives:1) verify any relationships existing between the values of the radiological score and the P/F at T0 and T30;2) verify the statistical significance found by applying the Wilcoxon test as an analysis test for the variation and the Pearson test for the correlation between the two parameters. Materials and Methods: The Wilcoxon paired data test was used to evaluate the variation of parameters between T0 and T30.The linear Pearson correlation evaluated the correlation between the variations of the two parameters. Results: Pearson correlation shows the median values of both parameters at T0 and at T30.There is a high inverse correlation between the change in P/F and in score (r=-0.82 p <0.001). Discussion: The CODIPAF study demonstrated a statistically significant correlation between the values of the CRX score and those of the P/F obtained at T0 and T30. Conclusions: The CODIPAF study showed how the radiological score obtained at T0 and T30 correlates with the P/F values always obtained at T0 and T30.
ABSTRACT
Background and Aim: The authors evaluated the prevalence of pulmonary embolism in 40 patients with SARS-CoV-2 related interstitial pneumonia, of which 20 with areas of ground glass and 20 with areas of crazy paving. The PREMOVID study, acrostic deriving from PREvalence of pulmonary embolism in CoViD-19, carried out a retrospective analysis on 40 patients enrolled with CoViD-19 pneumonia. The diagnosis was confirmed by the radiological picture (CT-CXR),by the positivity of the molecular swab for SARS-CoV-2. The PREMOVID study has the following objectives: 1) verify any relationships existing between the cases of pulmonary embolism in patients with areas of ground glass and areas of crazy paving;2) verify the statistical significance found by applying the Chi-square. Materials and Methods: The Chi-square test was used to compare the frequency of PE in the two groups of 20 patients with ground glass and crazy paving areas. Results: In total there are 8 (20%) cases of PE. In the Crazy group the percentage of patients with PE is significantly higher than in the Ground Glass group. Conclusions: The PREMOVID study demonstrated a statistically significant correlation between the number of cases of pulmonary embolism detected and the crazy paving tomographic variant. It is hypothesized that the crazy paving variant may be the trigger of pulmonary embolism.